Age-Related White Matter Changes

Age-Related White Matter Changes

Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the cli...

Age-related white matter changes in Asia

Age-related white matter changes are common in the elderly and are considered as manifestation of arteriolosclerotic small vessel disease. Most recent studies have shown that the white matter changes are associated with cognitive impairment and dementia, urinary incontinence, gait disturbances, depression and increased risk of stroke and death. Although the clinical phenotypes of the white matt...

Circulating endothelial progenitor cells and age-related white matter changes.

BACKGROUND AND PURPOSE The objective was to evaluate the relationship between circulating endothelial progenitor cells (EPC) and age-related white matter changes (ARWMC). Endothelial dysfunction plays a role in the development of ARWMC. EPC incorporate into sites endothelial damage and are thought to be involved in the repair of vascular risk factor induced endothelial injury. ARWMC can be eval...

Significance of age-related white matter lesions.

A probabilistic white matter atlas approach to assessing age related changes in the brain

Introduction: Spatial normalisation of diffusion data allows diffusion properties to be compared across a population without any bias from macrostructural differences in tissue anatomy. Standard approaches perform spatial normalisation of diffusion tensors. However streamline tractography through lattices of tensors is mainly suited to reconstruction of major white matter fibres. In contrast pr...